Bird LabRegulation of Microtubule Networks

The regulation of cell migration is a highly complex process that is often compromised when cancer cells become metastatic. The microtubule cytoskeleton is an important component within several cellular pathways that control cell migration, but how microtubules and microtubule-associated proteins regulate these pathways remains unclear. We have recently discovered a new microtubule-associated protein, GTSE1, that tracks growing microtubule plus-ends in cells and is important for cell migration. We are currently investigating the molecular mechanisms by which microtubules regulate cell migration capacity by studying GTSE1.

Relevant publications:  

Scolz, Widlund et al., PLoS One, 2012

Microtubules in the Regulation of Cell Migration

GTSE1 localizes to growing microtubule tips

Green; GTSE1 Red: microtubules